Preparation and Antibacterial Evaluation of Berberine Modified Carboxymethyl Cellulose
[1]CHEN Zhenzhen,LU Pei,FU Gui,et al.Preparation and Antibacterial Evaluation of Berberine Modified Carboxymethyl Cellulose[J].Journal of Zhengzhou University (Engineering Science),2023,44(02):104-110.[doi:10.13705/j.issn.1671-6833.2023.02.010]
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Journal of Zhengzhou University (Engineering Science)[ISSN
1671-6833/CN
41-1339/T] Volume:
44卷
Number of periods:
2023 02
Page number:
104-110
Column:
Public date:
2023-02-27
- Title:
- Preparation and Antibacterial Evaluation of Berberine Modified Carboxymethyl Cellulose
- Keywords:
- modified carboxymethyl cellulose; berberine; response surface methodology; bacteriostatic agent; paper protection
- CLC:
- O629. 3
- DOI:
- 10.13705/j.issn.1671-6833.2023.02.010
- Abstract:
- In order to protect paper and solve the problem of bacterial drug resistance, in this study, carboxymethyl cellulose and berberine were used as raw materials to prepare berberylated carboxymethyl cellulose (BBR-DCMC) through schiff base reaction. The single factor experiment and response surface method were used to optimize the preparation process, and disk AGAR diffusion method was used to determine the antibacterial activity. The results showed that when the mass ratio of dialdehyde carboxymethyl cellulose and modified berberine was 7 ∶15, reaction temperature was 39. 0 ℃ , and pH was 5. 0, the optimum synthetic conditions was obtained. And the model established by the response surface method was true and reliable. Besides, BBR-DCMC had good antibacterial and antifungal properties against bacteria and molds. The minimum inhibitory concentration of the product against Staphylococcus aureus and Escherichia coli were 0. 2 mg / mL, the minimum inhibitory concentrations against Aspergillus niger and Candida albicans were 0. 4 mg / ml. This research provided some theoretical guidance for the protection of paper cultural relics.
- References:
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Last Update:
2023-02-25