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Analysis of the Influence of the Non-uniform Distribution of Magnetic Field and Magnetic Fluid on the Temperature Field in Magnetic Induction Hyperthermia
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[1]Wang Ke,Zhang Hongbo,Anbo,et al.Analysis of the Influence of the Non-uniform Distribution of Magnetic Field and Magnetic Fluid on the Temperature Field in Magnetic Induction Hyperthermia[J].Journal of Zhengzhou University (Engineering Science),2021,42(04):40-46.[doi:10.13705/j.issn.1671-6833.2021.04.005]
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Journal of Zhengzhou University (Engineering Science)[ISSN 1671-6833/CN 41-1339/T] Volume: 42卷 Number of periods: 2021 04 Page number: 40-46 Column: Public date: 2021-07-30
Title:
Analysis of the Influence of the Non-uniform Distribution of Magnetic Field and Magnetic Fluid on the Temperature Field in Magnetic Induction Hyperthermia
Author(s):
Wang Ke; Zhang Hongbo; Anbo; Zhang Lu; Wang Yongqing;
School of Mechanics and Safety Engineering of Zhengzhou University; Key Laboratory of the Process and heat transfer of Zhengzhou University Henan Province; School of Mechanical and Power Engineering, Zhengzhou University;
Keywords:
magnetic fluid; hyperthermia; temperature field; magnetic field
CLC:
-
DOI:
10.13705/j.issn.1671-6833.2021.04.005
Abstract:
Since the uniformity of the temperature field distribution determines the therapeutic effect of magnetic fluid hyperthermia,the distribution characteristics of the temperature field are closely related to the magnetic field distribution and the magnetic fluid distribution.In this article,the non-uniform distribution of the magnetic field produced by the actual Helmholtz coil was considered,and the influence of the non-uniform distribution of the magnetic fluid on the temperature field were further explored based on the multi-point injection strategy,and a theoretical basis for the clinical application of magnetic fluid hyperthermia was provided.This paper took the temperature field distribution in biological tissues during magnetic fluid hyperthermia as the research object,and aimed to maximize the volume fraction in tumor tissues up to 42～46 ℃ to explore the influence of different center-border injection ratios on the temperature field,thereby increasing the uniformity of the temperature field distribution.The biological tissue was simplified into a concentric sphere model,and a physical model combining the magnetic field,the heat generation power of the magnetic fluid and the biological heat transfer was established,and the finite element method was used to numerically solve the model.In order to consider the actual situation of magnetic fluid hyperthermia,the physical model analyzed the difference in the distribution of blood perfusion rate and the concentration of magnetic fluid after the temperature of the biological tissue changes.The results indicated that with the increasing of the offset distance between the center of the biological tissue and magnetic field,the temperature difference increased;when the offset was 10 mm,it would cause a temperature difference of 1 ℃;therefore,when there was a big difference between the center of the biological tissue and the center of the magnetic field,the actual magnetic field distribution should be considered;non-equal dose multi-point injection could make more tumor tissues be in a reasonable treatment temperature range.When the injection ratio k was 1～2,the volume fraction would be more affected;reduced the maximum temperature in the tissue,so that more tumor tissues were in a reasonable treatment temperature range;when the injection volume remained the same,compared with the 5-point injection,the 7-point injection had a larger volume fraction at a reasonable temperature,and its temperature spatial distribution was more uniform.
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Last Update: 2021-08-26
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