Carbon Quantum Dots as Potent Agent to Induce Apoptosis of Human Hepatoma Cells

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Carbon Quantum Dots as Potent Agent to Induce Apoptosis of Human Hepatoma Cells

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[1]ZHANG Tao,GUO Yimin,LI Zhuoyang,et al.Carbon Quantum Dots as Potent Agent to Induce Apoptosis of Human Hepatoma Cells[J].Journal of Zhengzhou University (Engineering Science),2020,41(05):1-7.[doi:10.13705/j.issn.1671-6833.2020.05.001]

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Journal of Zhengzhou University (Engineering Science)[ISSN 1671-6833/CN 41-1339/T] Volume: 41卷 Number of periods: 2020 05 Page number: 1-7 Column: Public date: 2020-10-01

Title:: Carbon Quantum Dots as Potent Agent to Induce Apoptosis of Human Hepatoma Cells

Author(s):: ZHANG Tao1; 2; GUO Yimin2; LI Zhuoyang3; XI Guoguo2; ZUO Lei2; CAO Yongping3; WANG Yahong4; School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, Henan, School of Materials Science and Engineering, Beijing University of Aeronautics and Astronautics, Beijing 100191, School of Materials Science and Engineering, Beijing University of Aeronautics and Astronautics, Beijing 100191, Orthopedic Department of Peking University First Hospital, Beijing 100034, Harbin Cheng Cheng Cheng Cheng Cheng Cheng Life and Material Research Institute, Heilongjiang Harbin 150500

Keywords:: Carbon quantum dot; solution; cancer cells; human lymphocytes; apoptosis

CLC:: -

DOI:: 10.13705/j.issn.1671-6833.2020.05.001

Abstract:: The carbon quantum dots ( CQDs) colloid solution was prepared by electrolyzing graphite with pulsecurrent. The shape, size, structure and performance of the carbon quantum dots were characterized by trans-mission electron microscopy, X -ray diffractometer, Fourier transform infrared spectroscopy and fluorescencespectroscopy , etc. The CQDs were quasi-spherical particles with an average particle size of 6.93 nm, and thesurface contained a variety of oxygen-rich functional groups and showed fluorescence characteristics. The cyto-toxicity test showed that the colloid solution could induce the apoptosis of human hepatoma cells ( HepG2cells) , and thus could effectively inhibit the proliferation of the cells, when the concentration of CQDs colloidsolution was above a certain value. Transmission electron microscopy images of HepG2 cells after apoptosis in-duced by CQDs showed that their mitochondria were damaged. There was almost no effects on human lympho-cytes in the same CQDs concentration range. The CQDs colloid solution has the effect of selectively inducingapoptosis of HepG2 cells, which is of great significance for the research of new anti-cancer drugs without sideeffects.

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Last Update: 2020-10-23