NAVIGATE

Table of Contents

STATISTICS

Viewed2559

Downloads1830

Analysis of the Influence of the Non-uniform Distribution of Magnetic Field and Magnetic Fluid on the Temperature Field in Magnetic Induction Hyperthermia
[HTML]   PDF下载 (1830)
[1]Wang Ke,Zhang Hongbo,Anbo,et al.Analysis of the Influence of the Non-uniform Distribution of Magnetic Field and Magnetic Fluid on the Temperature Field in Magnetic Induction Hyperthermia[J].Journal of Zhengzhou University (Engineering Science),2021,42(04):40-46.[doi:10.13705/j.issn.1671-6833.2021.04.005]
Copy
Journal of Zhengzhou University (Engineering Science)[ISSN 1671-6833/CN 41-1339/T] Volume: 42 Number of periods: 2021 04 Page number: 40-46 Column: Public date: 2021-07-30
Title:
Analysis of the Influence of the Non-uniform Distribution of Magnetic Field and Magnetic Fluid on the Temperature Field in Magnetic Induction Hyperthermia
Author(s):
Wang Ke; Zhang Hongbo; Anbo; Zhang Lu; Wang Yongqing;
School of Mechanics and Safety Engineering of Zhengzhou University; Key Laboratory of the Process and heat transfer of Zhengzhou University Henan Province; School of Mechanical and Power Engineering, Zhengzhou University;
Keywords:
magnetic fluid; hyperthermia; temperature field; magnetic field
CLC:
-
DOI:
10.13705/j.issn.1671-6833.2021.04.005
Abstract:
Since the uniformity of the temperature field distribution determines the therapeutic effect of magnetic fluid hyperthermia,the distribution characteristics of the temperature field are closely related to the magnetic field distribution and the magnetic fluid distribution.In this article,the non-uniform distribution of the magnetic field produced by the actual Helmholtz coil was considered,and the influence of the non-uniform distribution of the magnetic fluid on the temperature field were further explored based on the multi-point injection strategy,and a theoretical basis for the clinical application of magnetic fluid hyperthermia was provided.This paper took the temperature field distribution in biological tissues during magnetic fluid hyperthermia as the research object,and aimed to maximize the volume fraction in tumor tissues up to 42～46 ℃ to explore the influence of different center-border injection ratios on the temperature field,thereby increasing the uniformity of the temperature field distribution.The biological tissue was simplified into a concentric sphere model,and a physical model combining the magnetic field,the heat generation power of the magnetic fluid and the biological heat transfer was established,and the finite element method was used to numerically solve the model.In order to consider the actual situation of magnetic fluid hyperthermia,the physical model analyzed the difference in the distribution of blood perfusion rate and the concentration of magnetic fluid after the temperature of the biological tissue changes.The results indicated that with the increasing of the offset distance between the center of the biological tissue and magnetic field,the temperature difference increased;when the offset was 10 mm,it would cause a temperature difference of 1 ℃;therefore,when there was a big difference between the center of the biological tissue and the center of the magnetic field,the actual magnetic field distribution should be considered;non-equal dose multi-point injection could make more tumor tissues be in a reasonable treatment temperature range.When the injection ratio k was 1～2,the volume fraction would be more affected;reduced the maximum temperature in the tissue,so that more tumor tissues were in a reasonable treatment temperature range;when the injection volume remained the same,compared with the 5-point injection,the 7-point injection had a larger volume fraction at a reasonable temperature,and its temperature spatial distribution was more uniform.
References:
[1] ABU-GHARBIEH E,KHALIDI D A,BAIG M R,et al.Refining knowledge,attitude and practice of evidence-based medicine (EBM)among pharmacy students for professional challenges[J].Saudi pharmaceutical journal,2015,23(2):162-166.
[2] ZUVIN M,KOÇAK M,ÜNAL Ö,et al.Nanoparticle based induction heating at low magnitudes of magnetic field strengths for breast cancer therapy[J].Journal of magnetism and magnetic materials,2019,483:169-177.
[3] LACHOWICZ D,SZPAK A,MALEK-ZIETEK K E,et al.Biocompatible and fluorescent superparamagnetic iron oxide nanoparticles with superior magnetic properties coated with charged polysaccharide derivatives[J].Colloids and surfaces:biointerfaces,2017,150:402-407.
[4] XIONG F,HU K,YU H L,et al.A functional iron oxide nanoparticles modified with PLA-PEG-DG as tumor-targeted MRI contrast agent[J].Pharmaceutical research,2017,34(8):1683-1692.
[5] DUTZ S,HERGT R.Magnetic nanoparticle heating and heat transfer on a microscale:basic principles,realities and physical limitations of hyperthermia for tumour therapy[J].International journal of hyperthermia,2013,29(8):790-800.
[6] WU L,CHENG J J,LIU W Z,et al.Numerical analysis of electromagnetically induced heating and bioheat transfer for magnetic fluid hyperthermia[J].IEEE transactions on magnetics,2015,51(2):1-4.
[7] PAVEL M,STANCU A.Study of the optimum injection sites for a multiple metastases region in cancer therapy by using MFH[J].IEEE transactions on magnetics,2009,45(10):4825-4828.
[8] 王永庆,查洋,王珂.肿瘤组织磁流体热疗过程中的影响因素分析[J].低温与超导,2019,47(7):44-49,67.
[9] ASTEFANOAEI I,DUMITRU I,CHIRIAC H,et al.Controlling temperature in magnetic hyperthermia with low Curie temperature particles[J].Journal of applied physics,2014,115(17):531-533.
[10] MITAL M,TAFRESHI H V.A methodology for determining optimal thermal damage in magnetic nanoparticle hyperthermia cancer treatment[J].International journal for numerical methods in biomedical engineering,2012,28(2):205-213.
[11] KANDALA S K,LIAPI E,WHITCOMB L L,et al.Temperature-controlled power modulation compensates for heterogeneous nanoparticle distributions:a computational optimization analysis for magnetic hyperthermia[J].International journal of hyperthermia,2019,36(1):115-129.
[12] LI J,YAO H,LEI Y,et al.Numerical simulation of magnetic fluid hyperthermia based on multiphysics coupling and recommendation on preferable treatment conditions[J].Current applied physics,2019,19(9):1031-1039.
[13] SALLOUM M,MA R H,WEEKS D,et al.Controlling nanoparticle delivery in magnetic nanoparticle hyperthermia for cancer treatment:experimental study in agarose gel[J].International journal of hyperthermia,2008,24(4):337-345.
[14] ROSENSWEIG R E.Heating magnetic fluid with alternating magnetic field[J].Journal of magnetism and magnetic materials,2002,252:370-374.
[15] SALLOUM M,MA R,ZHU L.Enhancement in treatment planning for magnetic nanoparticle hyperthermia:optimization of the heat absorption pattern[J].International journal of hyperthermia,2009,25(4):309-321.
[16] 吴晓,唐井元,张永才,等.单分子前躯体法合成Fe3O4纳米颗粒[J].郑州大学学报(工学版),2008,29(4):17-21,27.
[17] MAENOSONO S,SAITA S.Theoretical assessment of FePt nanoparticles as heating elements for magnetic hyperthermia[J].IEEE transactions on magnetics,2006,42(6):1638-1642.
[18] OBAIDAT I M,ISSA B,HAIK Y.Magnetic properties of magnetic nanoparticles for efficient hyperthermia[J].Nanomaterials,2015,5(1):63-89.
[19] KUMAR C S S R,MOHAMMAD F.Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery[J].Advanced drug delivery reviews,2011,63(9):789-808.
Similar References:
Memo

-

Last Update: 2021-08-26
Copyright © 2023 Editorial Board of Journal of Zhengzhou University (Engineering Science)