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Preparation of Polymorphism of Tetracaine Hydrochloride and Measurement and Correlation of the Solubility
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[1]LI Shasha,CHANG Yingjie,ZHAO Jie,et al.Preparation of Polymorphism of Tetracaine Hydrochloride and Measurement and Correlation of the Solubility[J].Journal of Zhengzhou University (Engineering Science),2020,41(06):92-96.[doi:10.13705/j.issn.1671-6833.2020.06.008]
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Journal of Zhengzhou University (Engineering Science)[ISSN 1671-6833/CN 41-1339/T] Volume: 41卷 Number of periods: 2020 06 Page number: 92-96 Column: Public date: 2020-12-31
Title:
Preparation of Polymorphism of Tetracaine Hydrochloride and Measurement and Correlation of the Solubility
Author(s):
LI Shasha1;  CHANG Yingjie2;  ZHAO Jie1;  DING Yuanmin1;  LI Ruipeng2;  LI Wen2; 3; 4; 5
1.School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China; 2.School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; 3.Henan Province Key Laboratory of Technology of Drug Preparation, Zhengzhou 450001, China; 4.Collaborative Innovation Center of New Drug Research, Zhengzhou 450001, China; 5.Safety Evaluation and Ministry of Education Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou 450001, China
Keywords:
tetracaine hydrochloride;  polymorphism;  solubility;  measurement;  correlation
CLC:
-
DOI:
10.13705/j.issn.1671-6833.2020.06.008
Abstract:
Tetracaine hydrochloride has polymorphic phenomena. The measurement of the solubility of crystalline drugs was a hot topic in the field of drug quality control. The solubility of commercial tetracaine hydrochloride was reported in the literature. The solubility of tetracaine hydrochloride was determined and correlated. On the basis of qualitative and quantitative analysis of polymorphic phenomena of tetracaine hydrochloride, balance method was selected to determin the solubility of commercial tetracaine hydrochloride in pure and mixed solvents. The results showed that tetracaine hydrochloride had the latent dissolution phenomenon in methanol-ethyl acetate mixed solvents. When the molar fraction of methanol was 0.849 2, the solubility reached the maximum. In pure solvents, the solubility datas of tetracaine hydrochloride coincided with the Apelblat equation. While in mixed solvents, the solubility datas of tetracaine hydrochloride coincided with the CNIBS/R-K equation.The correlation coefficients R2 between fitting results and experimental data was greater than 0.99. The dissolution entropy and enthalpy of tetracaine hydrochloride in the dissolution process were calculated by the van′t Hoff equation, which proved that the dissolution process of tetracaine hydrochloride was endothermic and entropy-driving.
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Last Update: 2021-02-10
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