Electronic Nose and Diagnosis Model for the Detection of Human Gastrointestinal Diseases Based on Hydrogen and Methane Breath Test

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Electronic Nose and Diagnosis Model for the Detection of Human Gastrointestinal Diseases Based on Hydrogen and Methane Breath Test

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[1]Govan,Zhang Xusheng,Wang Min,et al.Electronic Nose and Diagnosis Model for the Detection of Human Gastrointestinal Diseases Based on Hydrogen and Methane Breath Test[J].Journal of Zhengzhou University (Engineering Science),2019,40(06):32-37.[doi:10.13705/j.issn.1671-6833.2019.06.001]

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Journal of Zhengzhou University (Engineering Science)[ISSN 1671-6833/CN 41-1339/T] Volume: 40卷 Number of periods: 2019 06 Page number: 32-37 Column: Public date: 2019-11-16

Title:: Electronic Nose and Diagnosis Model for the Detection of Human Gastrointestinal Diseases Based on Hydrogen and Methane Breath Test

Author(s):: Govan 1; 2; Zhang Xusheng 1; Wang Min 1; Zhang Junyu 1; Wang Ping 1; 1. School of Biomedical Engineering and Instrument Science, Zhejiang University; 2. School of Automation, Nanjing University of Aeronautics and Astronautics

Keywords:: Methane hydrogen breath test; gastrointestinal diseases; electronic nose; SIBO diagnostic model

CLC:: TP212

DOI:: 10.13705/j.issn.1671-6833.2019.06.001

Abstract:: Hydrogen and methane breath test has been widely used in the diagnosis of sugar intolerance, small intestinal bacterial overgrowth (SIBO) and other gastrointestinal diseases. The gold standard for clinical diagnosis of SIBO is small intestinal fluid culture, while the sampling is invasive and the sample location is limited and easy to be contaminated. Therefore, clinical experience is often used for the diagnosis of SIBO with poor accuracy and risk of abusing the antibiotics. In this paper, hydrogen and methane in breath were selected as the markers and a novel electronic nose was developed which can detect the concentration of hydrogen and methane in breath with the detection range is 1-200 ppm, the resolution is 1 ppm, and the precision is less than 10%. The results were corrected by the carbon dioxide concentration to eliminate the effect of the dilution of outside gas, the patient breathing mode and other factors on the alveolar gas. The 47 cases of healthy people and patients were collected, and the types of concentration curve were judged accurately, and the SIBO diagnostic model was established. This method has the advantages of high specificity, non-invasive and simplicity of operation, so that can be used for the detection of increasing volume of clinical and domestic patients.

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Last Update: 2019-11-25