Formation of Flunarizine Hydrochloride Particles via Rapid Expansion of Supercritical Solution Process
[1]Hu Guoqin,Sun Fangxing,Liu Jinghui,et al.Formation of Flunarizine Hydrochloride Particles via Rapid Expansion of Supercritical Solution Process[J].Journal of Zhengzhou University (Engineering Science),2019,40(06):57-61.[doi:10.13705/j.issn.1671-6833.2018.06.011]
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Journal of Zhengzhou University (Engineering Science)[ISSN
1671-6833/CN
41-1339/T] Volume:
40
Number of periods:
2019 06
Page number:
57-61
Column:
Public date:
2019-11-16
- Title:
- Formation of Flunarizine Hydrochloride Particles via Rapid Expansion of Supercritical Solution Process
- Keywords:
- Flunarizine hydrochloride; Micronization; Supercritical solution rapid expansion process; Orthogonal experiment; characterization
- CLC:
- R944.9
- DOI:
- 10.13705/j.issn.1671-6833.2018.06.011
- Abstract:
- In this study, FH is micronized via Supercritical solution rapid expansion process (RESS) to improve its dissolution rate of drug in the biological environment. And the effects of the process parameters such as the temperature and the pressure of equilibrium cell, the temperature of the collection vessel, the temperature of the nozzle, the diameter of the nozzle and the concentration of the entrainer on the size and morphology of the drug particles were investigated.The particles before and after RESS were characterized by optical microscopy，scanning electron microscope (SEM), X-ray diffraction (XRD) and thermogravimetry (TGA). Test results show that microparticles of FH was successfully performed by using RESS and The average particle size of Flourarizine Hydrochloride were in the range of 1.285μm to 6.893μm. The results of FT-IR, XRD, and TG-DSC indicate that the physical and chemical properties of flunarizine hydrochloride particles remained stable before and after the RESS process
- References:
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Last Update:
2019-11-25