Multimodal Cross-scale Feature Fusion for Drug-Target Affinity Prediction

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Multimodal Cross-scale Feature Fusion for Drug-Target Affinity Prediction

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[1]ZHENG Hong,LUO Yujian,LING Kan,et al.Multimodal Cross-scale Feature Fusion for Drug-Target Affinity Prediction[J].Journal of Zhengzhou University (Engineering Science),2026,47(4):58-65.[doi:10.13705/j.issn.1671-6833.2026.04.001]

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Journal of Zhengzhou University (Engineering Science)[ISSN 1671-6833/CN 41-1339/T] Volume: 47 Number of periods: 2026 Issue 4 Page number: 58-65 Column: Public date: 2026-07-10

Title:: Multimodal Cross-scale Feature Fusion for Drug-Target Affinity Prediction

Author(s):: ZHENG Hong, LUO Yujian, LING Kan, FAN Guisheng; School of Information Science and Engineering, East China University of Science and Technology, Shanghai 200237,China

Keywords:: graph neural network; drug-target affinity prediction; feature learning; cross-scale feature fusion; drug development

CLC:: TP183R91R318

DOI:: 10.13705/j.issn.1671-6833.2026.04.001

Abstract:: To address the current challenges in relying solely on single-modal features of target proteins and neglec-tingnetwork-scale features of biological networks, a drug-target affinity prediction (DTA) model based on multimo-dalcross-scale feature fusion was proposed. Target proteins both as sequences and graphs for feature extraction were presented, with semantic and topological features respectively, to enhance the target proteins′ feature representa-tion.The strong affinity relationships between drugs and target proteins were analyzed to construct a heterogeneous graph network of drug-target interaction. A cross-scale feature fusion method was then used to effectively integrate the scale features of the heterogeneous graph network, then to enrich the feature representations of both target pro-teinsand drug molecules. Experimental results on the DAVIS and KIBA datasets demonstrated that, compared with the more advanced model SISDTA, the proposed model achieved reductions in MSE by 0. 015 and 0. 003, respectively,and increases in CI by 0. 005 and 0. 004, respectively, improving the accuracy and stability of affinity pre-diction.It demonstrated the effectiveness of multimodal and cross-scale feature fusion in DTA prediction tasks.

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Last Update: 2026-10-21