Research of the Chemical Resolution Process for Pregabalin
[1]Ll Wen,LIU Chun-xia,YU Yu-zheng,et al.Research of the Chemical Resolution Process for Pregabalin[J].Journal of Zhengzhou University (Engineering Science),2015,36(04):33-36.[doi:10.3969/j.issn.1671-6833.2015.04.008]
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Journal of Zhengzhou University (Engineering Science)[ISSN
1671-6833/CN
41-1339/T] Volume:
36
Number of periods:
2015 04
Page number:
33-36
Column:
Public date:
2015-08-31
- Title:
- Research of the Chemical Resolution Process for Pregabalin
- Keywords:
- S-Mandelic acid ; chemical resolution ; preparation
- CLC:
- R971.6
- Abstract:
- This paper studies the chemical resolution process of Pregabalin.Process for resolving racemic Pre-gabalin to S- Pregabalin by using S- mandelic acid as the resolving agent, the content of each component in theresolution process were determined by HPLC method. The optimum resolution conditions were obtained by theinvestigations of the rule in the content variations of different components under different conditions and veri-fied by the further tests. The optimum resolution conditions obtained from this study have good repeatability ,and the content of Pregabalin could reach more than 99.5% which fully meets the requirements of Pharmaco-poeia， the amount per batch of qualified products is not less than 100 g. This study provides a valuable theo-retical foundation for the industrialized preparation of Pregabalin.
- References:
- -
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