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Study on Optimization of 5-Fluorouracil Magnetic Solid Lipid Nanoparticles
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[1]SHEN Guopeng,LIANG Chunli,GE Qingping,et al.Study on Optimization of 5-Fluorouracil Magnetic Solid Lipid Nanoparticles[J].Journal of Zhengzhou University (Engineering Science),2010,31(03):16-19.
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Journal of Zhengzhou University (Engineering Science)[ISSN 1671-6833/CN 41-1339/T] Volume: 31卷 Number of periods: 2010 No.03 Page number: 16-19 Column: Public date: 2010-03-01
Title:
Study on Optimization of 5-Fluorouracil Magnetic Solid Lipid Nanoparticles
Author(s):
SHEN Guopeng; LIANG Chunli; GE Qingping; etc
1．School of ChemicM Engineering and Energy，Zhengzhou University，Zhengzhou 450001，China；2．Henan Institute of ProductsQuality Supervision and Inspection。Zhengzhou 450052，China；3．School of Pharmaceutical Sciences，Zhengzhou University，Zhengzhou 450001，China
Keywords:
5-Fluorouracil; magnetic solid lipid nanoparticle; optimization; encapsulation rate
CLC:
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DOI:
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Abstract:
To improve the therapeutic efficacy and reduce the toxicity of 5-Fluorouracil(5-FU)，5-Flu-orouracil magnetic solid lipid nanoparticles(5-FU-MSLN)were prepared with a W／O／W double emulsionsolvent evaporation technique，using monostearin as the carrier，hydrogenated soybean lecithin and poloxameras emulsifier，magnetic Fe3 04 nanoparticles as magnets．With jhe index of encapsulation efficiency，the prep—aration process was optimized By single—factor test and orthogonal test．As a result，the encapsulation efficiency of 5-FU-MSLN was 58．35％．TEM presented 5-FU-MSLN as spherical particles．evenly distrib·uted：5一FU—MSLN were observed under the inverted microscope，of which vitro magnetic responsivenesswas good．Such magnetic solid lipid nanoparticles seem appropriate for vascular administration followed bydrug targeting．
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