Synthesis of -L-(2R,3R)-(-)-dibenzoyl tartaric acid monohydrate

tartaric acid;  Benzoic acid;  Thionyl chloride;  Dibenzoyl tartaric acid;  Synthesis

L-(2R,3R)-(-)-dibenzoyl tartaric acid monohydrate is an important chiral drug splitting agent, but it is expensive, so we have investigated its synthesis method. Using 2R, 3R-tartaric acid, benzoic acid, thionyl chloride as raw materials, benzoylation with dehydration reaction to generate dibenzoyl tartaric anhydride, and then hydrolysis of acid anhydride to obtain the target product, in terms of tartaric acid, the total yield of dibenzoyl tartaric acid monohydrate is 70.9%, the method uses thionyl chloride to acyllate the reaction generated by benzoic acid and reuse, the reaction yield is high, the post-treatment is simple. The structure of the product was determined by optical rotation, which was consistent with the reported results. The process conditions of this method are easy to control and the pollution is less.