Synthesis of 2-amino-3-(trifluoromethyl)benzoic acid

2-Amino-3-(trifluoromethyl)benzoic acid;  chloral hydrate;  Synthesis

2-Amino-3-(trifluoromethyl)benzoic acid is an important drug synthesis intermediate, and its synthesis method has been studied. 2-trifluoromethylaniline, chloral hydrate and hydroxylamine hydrochloride were used as raw materials to synthesize 2-amino derivatives, and then converted into o-dicarbonyl derivatives in concentrated sulfuric acid, and finally 2-amino-3-trifluoromethylbenzoic acid was obtained by oxidation with hydrogen peroxide in sodium hydroxide aqueous solution. The total yield of 2-amino-2-(trifluoromethyl)benzoic acid was 3.53% based on 6-(trifluoromethyl)aniline. The synthesis method is easy to operate and has high yield, and all the synthesis steps of the method are water-phase reaction, which is easy to industrialize.