[1]LI Wen,You Qidong.Synthesis of 2-amino-3-(trifluoromethyl)benzoic acid[J].Journal of Zhengzhou University (Engineering Science),2004,25(03):29-32.[doi:10.3969/j.issn.1671-6833.2004.03.008]
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Journal of Zhengzhou University (Engineering Science)[ISSN
1671-6833/CN
41-1339/T] Volume:
25卷
Number of periods:
2004年03期
Page number:
29-32
Column:
Public date:
1900-01-01
- Title:
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Synthesis of 2-amino-3-(trifluoromethyl)benzoic acid
- Author(s):
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LI Wen; You Qidong
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- Keywords:
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- CLC:
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- DOI:
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10.3969/j.issn.1671-6833.2004.03.008
- Abstract:
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2-Amino-3-(trifluoromethyl)benzoic acid is an important drug synthesis intermediate, and its synthesis method has been studied. 2-trifluoromethylaniline, chloral hydrate and hydroxylamine hydrochloride were used as raw materials to synthesize 2-amino derivatives, and then converted into o-dicarbonyl derivatives in concentrated sulfuric acid, and finally 2-amino-3-trifluoromethylbenzoic acid was obtained by oxidation with hydrogen peroxide in sodium hydroxide aqueous solution. The total yield of 2-amino-2-(trifluoromethyl)benzoic acid was 3.53% based on 6-(trifluoromethyl)aniline. The synthesis method is easy to operate and has high yield, and all the synthesis steps of the method are water-phase reaction, which is easy to industrialize.