Polyethylene glycol phase transfer catalyzed synthesis of p-nitroanisole process

phase transfer catalysis;  synthesis;  p-Nitroanisole;  Polyethylene glycol

The synthesis of p-nitroanisole from p-nitrochlorobenzene from p-nitrochlorobenzene with different molecular weights polyethylene glycol (PEG) as a phase transfer catalyst was studied, the effects of polyethylene glycol molecular weight and the number of polyoxyethylene (-OCH2CH2-) unit links (also known as average polymerization) in the molecular structure on the reaction rate were investigated, the effects of sodium hydroxide, catalyst concentration and dosage on the reaction were investigated, and the catalytic reaction mechanism of PEG phase transfer was elaborated. A suitable process condition for the synthesis of p-nitroanisole under the catalytic condition of PEG phase transfer was established, that is, the temperature was 78~80 °C, n(PCNB)∶n(CH3OH)∶n(NaOH)∶n(P EG-400)=1∶3∶3∶(0.025~0.05), and the reaction time was about 7~8 h