Biotransformation of Dihydroepiandrosterone and the Synthesis andCytotoxic Activities of the16-Benzylidene Derivatives

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Biotransformation of Dihydroepiandrosterone and the Synthesis andCytotoxic Activities of the16-Benzylidene Derivatives

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[1]SHAN Li-hongQIAO Xing,Ll Yang,ZHANG Lu-jia,et al.Biotransformation of Dihydroepiandrosterone and the Synthesis andCytotoxic Activities of the16-Benzylidene Derivatives[J].Journal of Zhengzhou University (Engineering Science),2013,34(1):62-.[doi:10.3969/j.issn.1671-6833.2013.01.015]

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Journal of Zhengzhou University (Engineering Science)[ISSN 1671-6833/CN 41-1339/T] Volume: 34 Number of periods: 2013 Issue 1 Page number: 62- Column: Public date: 2013-01-16

Title:: Biotransformation of Dihydroepiandrosterone and the Synthesis andCytotoxic Activities of the16-Benzylidene Derivatives

Author(s):: SHAN Li-hong1,2QIAO Xing1,2,Ll Yang1,2,ZHANG Lu-jia1,2,JIA0 Kai1,2,LIU Hong-min1,2; 1.School of Pharmaceutical Science, Zhengzhou University , Zhengzhou 450001, China;2. New Drug Research and Develop-ment Center，Zhengzhou University，Zhengzhou 450001 ，China

Keywords:: dihydroepiandrosterone; Mucor cireinelloides ; 7-hydroxylation; 16-benzylidene derivatives; cyto-toxic activity

CLC:: R914.5

DOI:: 10.3969/j.issn.1671-6833.2013.01.015

Abstract:: Dihydroepiandrosterone (DHEA ) is one important bioactivity compound and one important interme-diate of steroid drugs. It is for the first time to report the biotransformation of DHEA by Mucor circinelloidesand two products was obtained. Furthermore,the 16-benzylidene derivatives were synthesized by Claison -Schimidt reaction. The cytotoxic evaluation showed that these derivatives had better activity than the parentcompound.

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