[1]SHAN Li-hongQIAO Xing,Ll Yang,ZHANG Lu-jia,et al.Biotransformation of Dihydroepiandrosterone and the Synthesis andCytotoxic Activities of the16-Benzylidene Derivatives[J].Journal of Zhengzhou University (Engineering Science),2013,34(01):62-.[doi:10.3969/j.issn.1671-6833.2013.01.015]
Copy
Journal of Zhengzhou University (Engineering Science)[ISSN
1671-6833/CN
41-1339/T] Volume:
34卷
Number of periods:
2013 01
Page number:
62-
Column:
Public date:
2013-01-16
- Title:
-
Biotransformation of Dihydroepiandrosterone and the Synthesis andCytotoxic Activities of the16-Benzylidene Derivatives
- Author(s):
-
SHAN Li-hong1; 2QIAO Xing1; 2; Ll Yang1; 2; ZHANG Lu-jia1; 2; JIA0 Kai1; 2; LIU Hong-min1; 2
-
1.School of Pharmaceutical Science, Zhengzhou University , Zhengzhou 450001, China;2. New Drug Research and Develop-ment Center,Zhengzhou University,Zhengzhou 450001 ,China
-
- Keywords:
-
dihydroepiandrosterone; Mucor cireinelloides ; 7-hydroxylation; 16-benzylidene derivatives; cyto-toxic activity
- CLC:
-
R914.5
- DOI:
-
10.3969/j.issn.1671-6833.2013.01.015
- Abstract:
-
Dihydroepiandrosterone (DHEA ) is one important bioactivity compound and one important interme-diate of steroid drugs. It is for the first time to report the biotransformation of DHEA by Mucor circinelloidesand two products was obtained. Furthermore,the 16-benzylidene derivatives were synthesized by Claison -Schimidt reaction. The cytotoxic evaluation showed that these derivatives had better activity than the parentcompound.