Taking the content of hibiscus proanthocyanidins as the investigation index, the effects of extractant concentration, extraction temperature, extraction time, material-liquid ratio and other factors on the extraction effect of proanthocyanidins were studied, and the optimal extraction conditions of hibiscus proanthocyanidins were determined by orthogonal experiments: 90% ethanol solution of extractant, extraction temperature 70 °C, extraction time 30 min, and material-liquid ratio of 1∶9 (g∶mL).