[1]周岩,李伟民,袁黎明..新型GC固定相的制备及其对手性化合物的拆分研究[J].郑州大学学报(工学版),2007,28(04):34-38.[doi:10.3969/j.issn.1671-6833.2007.04.009]
　ZHOU Yan,Li Weimin,Yuan Liming.Preparation of novel GC stationary phases and their splitting studies of chiral compounds[J].Journal of Zhengzhou University (Engineering Science),2007,28(04):34-38.[doi:10.3969/j.issn.1671-6833.2007.04.009]

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新型GC固定相的制备及其对手性化合物的拆分研究()

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《郑州大学学报(工学版)》[ISSN:1671-6833/CN:41-1339/T]

卷:

28卷

期数:

2007年04期

页码:

34-38

栏目:

出版日期:

1900-01-01

文章信息/Info

Title:

Preparation of novel GC stationary phases and their splitting studies of chiral compounds

作者:

周岩; 李伟民; 袁黎明.

郑州市环境保护监测中心站,河南,郑州,450007, 郑州市环境保护局,河南,郑州,450007, 云南师范大学,化学化工学院,云南,昆明,650092

Author(s):

ZHOU Yan; Li Weimin; Yuan Liming

关键词:

纤维素三(3; 5-二甲基苯基氨基甲酸酯);  气相色谱固定相;  手性化合物;  拆分

Keywords:

Cellulose tris(3;  5-Dimethylphenylcarbamate);  gas chromatography stationary phase;  chiral compounds;  Split

DOI:

10.3969/j.issn.1671-6833.2007.04.009

文献标志码:

A

摘要:

合成了纤维素三(3,5-二甲基苯基氨基甲酸酯)并用作气相色谱固定相,制备出手性毛细管柱,考察它的极性、柱效和手性选择性.研究表明,该固定相为中等极性,理论塔板数达1 895 m-1,容量因子1.52.该柱成功地分离了随机选取的25种(包括醇、醚、胺、酯、醛、酮、氨基酸类)外消旋化合物中的20种,其中以(±)-Dihydrocarvylacetate、(±)-Roseoxide、 (±)-N-Benzyl-1-phenylethylamine、(±)-Fenchone、DL-Leucine、DL-Isoleucine拆分效果较好,证实该柱具有良好的手性分离性能,可用于气相色谱.

Abstract:

Cellulose tris(3,5-dimethylphenylcarbamate) was synthesized and used as a stationary phase by gas chromatography to prepare chiral capillary columns to investigate its polarity, column efficiency and chiral selectivity. The results showed that the stationary phase was moderately polar, with a theoretical plate count of 1 895 m-1 and a capacity factor of 1.52.The column successfully isolated 25 of the 20 randomly selected racemic compounds (including alcohols, ethers, amines, esters, aldehydes, ketones, amino acids), including (±)-Dihydrocarvylacetate, (±)-Roseoxide, (±)-N-Benzyl-1-phenylethylamine, (±)- Fenchone, DL-Leucine and DL-Isoleucine had good separation effects, which confirmed that the column had good chiral separation performance and could be used in gas chromatography.

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