[1]李雯,刘宏民,肖志昂..对羟基苯甲酸-4-β-D-2’,3’,4’,6’-四乙酰葡萄糖甙-1-D-2’,3’,4’,6’-四乙酰葡萄糖酯的合成研究[J].郑州大学学报(工学版),2002,23(03):10-12.[doi:10.3969/j.issn.1671-6833.2002.03.003]
　LI Wen,LIU Hongmin,Xiao Zhiang.Study on the synthesis of 4-β-D-2’,3’,4’,6’-tetraacetylglucoside-1-D-2’,3’,4’,6’-tetraacetylglucosamine[J].Journal of Zhengzhou University (Engineering Science),2002,23(03):10-12.[doi:10.3969/j.issn.1671-6833.2002.03.003]

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对羟基苯甲酸-4-β-D-2’,3’,4’,6’-四乙酰葡萄糖甙-1-D-2’,3’,4’,6’-四乙酰葡萄糖酯的合成研究()

分享到：

《郑州大学学报(工学版)》[ISSN:1671-6833/CN:41-1339/T]

卷:

23

期数:

2002年03期

页码:

10-12

栏目:

出版日期:

1900-01-01

文章信息/Info

Title:

Study on the synthesis of 4-β-D-2’,3’,4’,6’-tetraacetylglucoside-1-D-2’,3’,4’,6’-tetraacetylglucosamine

作者:

李雯; 刘宏民; 肖志昂.

郑州大学化工学院,河南,郑州,450002, 郑州大学化学系,河南,郑州,450052, 郑州化工厂,河南,郑州,450048

Author(s):

LI Wen; LIU Hongmin; Xiao Zhiang

关键词:

端粒酶抑制活性;  对羟基苯甲酸-4-β-D-2’;  3’;  4’;  6’-四乙酰葡萄糖甙-1-D-2’;  6’-四乙酰葡萄糖酯;  合成

Keywords:

Telomerase inhibitory activity;  4-β-D-2’;  3’;  4’;  6’-Tetraacetylglucoside-1-D-2’;  6’-Tetraacetylglucosate;  Synthesis

DOI:

10.3969/j.issn.1671-6833.2002.03.003

文献标志码:

A

摘要:

端粒酶被认为是恶性肿瘤诊断和治疗的新耙标,对端粒酶有强抑制活性的对羟基苯甲酸-4-β-D-2’,3’,4’,6’-四乙酰葡萄糖甙-1-D-2’,3’,4’,6’- 四乙酰葡萄糖酯的合成进行了研究.通过采用丙酮法和相转移催化进行比较,可知相转移催化法收率更高,以葡萄糖计总收率可达到21%.所得的产物结构经元素分析、红外光谱、核磁共振谱所证实.

Abstract:

Telomerase is considered to be a new rake for the diagnosis and treatment of malignant tumors, and the synthesis of parahydroxybenzoic acid-4-β-D-2’,3’,4’,6’-tetraacetylglucoside-1-D-2’,3’,4’,6’-tetraacetylglucosate with strong inhibitory activity on telomerase has been studied. By comparing acetone method and phase transfer catalysis, it can be seen that the yield of phase transfer catalysis is higher, and the total yield of glucose can reach 21%.

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