Introduce the process of wet acid delysis of copper oxide ore and co-production of copper sulfate and iron oxide. The process flow is to acid leach the copper ore powder, crystallize first, and then replace the copper sulfate mother liquor to remove impurities, and the iron salt in the impurity removal process is prepared to obtain iron oxide. The effects of reaction acid concentration, acid leaching time, liquid-solid ratio and roasting temperature on wet production were discussed, and the optimal process conditions were determined as follows: sulfuric acid concentration 20%, time 3 h, liquid-solid ratio 2.8∶1, temperature 580 °C. Experiments show that the copper sulfate and iron oxide co-produced by this process meet national standards and are feasible in industrial production.