School of Chemical Technology, Zhengzhou University, 450001, Zhengzhou, Henan, School of Pharmacy, Zhengzhou University, Zhengzhou 450001 Henan, School of Pharmacy, Zhengzhou University, 450001, Zhengzhou, Henan, Key Laboratory of the Ministry of Education, Pharmaceutical Key Preparation Technology, Henan Zhengzhou 450001, new drug creation and drug safety evaluation Henan Province Henan Province Collaborative Innovation Center, Henan Zhengzhou 450001, Henan Provincial Pharmaceutical Quality Control and Evaluation Key Laboratory, Henan Zhengzhou 450001