[1]沈国鹏,梁春丽,葛庆平,等.5-氟尿嘧啶磁性固体脂质纳米粒制备工艺优化研究[J].郑州大学学报(工学版),2010,31(03):16-19.[doi:10.3969/j.issn.1671-6833.2010.03.005]
　Shen Guopeng,LIANG Chunli,GE Qingping,et al.Optimization of preparation process of 5-fluorouracil magnetic solid lipid nanoparticles[J].Journal of Zhengzhou University (Engineering Science),2010,31(03):16-19.[doi:10.3969/j.issn.1671-6833.2010.03.005]
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5-氟尿嘧啶磁性固体脂质纳米粒制备工艺优化研究()
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《郑州大学学报(工学版)》[ISSN:1671-6833/CN:41-1339/T]

卷:
31卷
期数:
2010年03期
页码:
16-19
栏目:
出版日期:
2010-03-01

文章信息/Info

Title:
Optimization of preparation process of 5-fluorouracil magnetic solid lipid nanoparticles
作者:
沈国鹏; 梁春丽; 葛庆平; 等.
郑州大学,化工与能源学院,河南,郑州,450001, 河南省产品质量监督检验院,河南,郑州,450052, 郑州大学,药学院,河南,郑州,450001
Author(s):
Shen Guopeng; LIANG Chunli; GE Qingping; etc
关键词:
5-氟尿嘧啶;  磁性固体脂质纳米粒;  工艺优化;  包封率
Keywords:
DOI:
10.3969/j.issn.1671-6833.2010.03.005
文献标志码:
A
摘要:
为提高5-氟尿嘧啶(5-Fu)制剂的疗效,降低毒副作用,以单硬脂酸甘油酯为载体,氢化大豆卵磷脂、泊洛沙姆为乳化剂,磁性纳米四氧化三铁为磁体,采用复乳-溶剂挥发法制备5-氟尿嘧啶磁性固体脂质纳米粒(5-Fu-MSLN).以包封率为考察指标,通过单因素实验和正交设计对制备工艺进行优化,所制备的5-Fu-MSLN包封率为58.35%.用透射电镜观察,磁性固体脂质纳米粒外观形态圆整,粒径分布均匀;在倒置的显微镜下观察,磁性固体脂质纳米粒体外磁响应性良好,实验结果表明,5-FU-MSLN是有希望的静脉给药靶向制剂.
Abstract:
In order to improve the efficacy of 5-fluorouracil (5-Fu) preparation and reduce the toxic side effects, 5-fluorouracil magnetic solid lipid nanoparticles (5-Fu-MSLN) were prepared by re-emulsification-solvent volatilization method with glyceryl monostearate as the carrier, hydrogenated soy lecithin and poloxamer as emulsifiers, and magnetic nano-ferric oxide as magnets. Observed by transmission electron microscopy, the appearance of magnetic solid lipid nanoparticles was round, and the particle size distribution was uniform. Observed under an inverted microscope, magnetic solid lipid nanoparticles have good in vitro magnetic responsiveness, and experimental results show that 5-FU-MSLN is a promising targeted preparation for intravenous administration.

更新日期/Last Update: 1900-01-01