Using the computational fluid dynamics software FLUENT, the heat transfer under the flow impact angle of 45°, 60°, 75° and 90°, and the fluid flows around 6 rows and 87 staggered tube bundles is simulated in 9D. The longitudinal and transverse tube spacings of the tube bundle were 5.11 mm and 5 mm, respectively.The average heat transfer Nussel number and model inlet and outlet pressure drop of the tube bundle were investigated, and compared with the experimental correlation formula of Rukauskas, when the Reynolds number was 000 20~000 4, the fitting formula of Nussel number of the tube bundle under the flow impact angle was given, and the local heat transfer characteristics of the tube circumference were meso-analyzed. The results show that the turbulent boundary layer is separated from the pipe wall when the circumferential angle is about 105°, and the heat transfer is the worst. The larger the flow impact angle, the greater the average heat exchange Nussel number of the tube bundle and the pressure drop at the inlet and outlet of the model. When the flow impact angle is 45°, the comprehensive heat transfer performance is better.