In order to improve the anticoagulant properties of silk fibrous material, it was tried to modify it with Chuanxiong, the active ingredient of the Chinese herbal medicine Chuanxiong. Firstly, the side chain of Chuanxiongzine was structurally modified to introduce the active group hydroxyl, and then the double bond was introduced by esterification reaction, and the obtained intermediate was further grafted and polymerized on the surface of silk fibrous material without initiator. The structure of modified silk was identified by Fourier transform infrared spectroscopy (FTIR), Fourier transform attenuated total reflection infrared spectroscopy (ATR-FTIR), and scanning electron microscopy (SEM). The anticoagulant performance of modified silk pigment was evaluated by partial thromboplastin time (APTT) and platelet adhesion, and compared with unmodified silk pigment, the APTT time of modified silk fibroin was prolonged, and no adhesion platelets were found after 30 minutes of culture in platelet-rich plasma, indicating that the anticoagulant activity of Chuanxiongzine derivative modified silk material in vitro was improved.