The chemical synthesis method of arbutin has been studied. By phase transfer catalysis, tetrabutylammonium bromide was used as a catalyst and glycoside reaction was carried out under atmospheric pressure, and the pentasylarbutin was obtained by deprotective group with a total yield of 44% (in terms of glucose), and the product structure was confirmed by elemental analysis, infrared spectroscopy and nuclear magnetic resonance spectroscopy. This method is atmospheric pressure reaction, and the raw materials are easy to obtain, the operation is simple, the equipment requirements are not high, and it has certain industrial production value.