基于甲烷氢呼气的人体胃肠道疾病检测电子鼻及诊断模型-《郑州大学学报(工学版)》

文章信息/Info

Title:: Electronic Nose and Diagnosis Model for the Detection of Human Gastrointestinal Diseases Based on Hydrogen and Methane Breath Test

Author(s):: Govan 1; 2; Zhang Xusheng 1; Wang Min 1; Zhang Junyu 1; Wang Ping 1; 1. School of Biomedical Engineering and Instrument Science, Zhejiang University; 2. School of Automation, Nanjing University of Aeronautics and Astronautics

Keywords:: Methane hydrogen breath test; gastrointestinal diseases; electronic nose; SIBO diagnostic model

摘要:: 甲烷氢呼气试验已被广泛应用于诊断糖类不耐受、小肠细菌过度增长（small intestinal bacterial overgrowth, SIBO）等胃肠道疾病。SIBO临床诊断的金标准为小肠液培养，但需侵入式取样，部位受限且易被污染，故临床多采用经验诊疗，准确性差且存在滥用抗生素的风险。本项目选取氢气、甲烷作为标志物，设计了人体胃肠道疾病呼气检测电子鼻，可快速检测呼气中氢气和甲烷浓度（检测范围1-200 ppm，分辨率1 ppm，精度小于10 %）并根据二氧化碳浓度修正，排除室外气体稀释、病人呼吸模式等因素对肺泡气的影响。实测健康人与患者样本47例，精确判断浓度曲线类型，建立SIBO诊断模型。本文设计的检测系统具有准确性高、无创便捷等优势，在未来可用于大规模的临床与家庭病人的数据采集与诊断分析。

Abstract:: Hydrogen and methane breath test has been widely used in the diagnosis of sugar intolerance, small intestinal bacterial overgrowth (SIBO) and other gastrointestinal diseases. The gold standard for clinical diagnosis of SIBO is small intestinal fluid culture, while the sampling is invasive and the sample location is limited and easy to be contaminated. Therefore, clinical experience is often used for the diagnosis of SIBO with poor accuracy and risk of abusing the antibiotics. In this paper, hydrogen and methane in breath were selected as the markers and a novel electronic nose was developed which can detect the concentration of hydrogen and methane in breath with the detection range is 1-200 ppm, the resolution is 1 ppm, and the precision is less than 10%. The results were corrected by the carbon dioxide concentration to eliminate the effect of the dilution of outside gas, the patient breathing mode and other factors on the alveolar gas. The 47 cases of healthy people and patients were collected, and the types of concentration curve were judged accurately, and the SIBO diagnostic model was established. This method has the advantages of high specificity, non-invasive and simplicity of operation, so that can be used for the detection of increasing volume of clinical and domestic patients.