Taking a high-rise frame-eccentric support steel structure house as the engineering background, the finite element software SAP2000 was used to model the structural stiffness, internal force distribution, vibration mode and load-displacement curve under rare earthquakes, and a number of seismic waves were used to compare the elastic time history and elastoplastic time history of the central support and eccentric support structural systems, and the dynamic characteristics and seismic performance of the two structural systems were compared. The analysis shows that the anti-lateral stiffness of the high-rise frame-eccentric support steel structure system can meet the requirements of structural anti-lateral shift. Under the action of repeated earthquakes, the eccentric support structure system has obvious energy dissipation, and the structural dynamic response is less than that of the central support system. Under the action of rare earthquakes, the stiffness attenuation of the eccentric support structure is small after entering the plastic stage, and the lateral stiffness and bearing capacity can still be maintained, which shows the ductility characteristics of which are significantly better than the central support system, and the seismic performance is better than that of the central support system.