In order to study the shrinkage defects of titanium alloy centrifugal casting in depth, microcrystalline wax was used as the physical simulation medium, and the shrinkage defects during the solidification and forming of titanium alloy under centrifugal force field were simulated according to similar criteria, and the influence of rotation speed and centrifugal holding time on shrinkage defects of centrifugal casting was studied. The experimental results show that with the increase of rotation speed, the volume of shrinkage defects at the riser of the microcrystalline wax coagulator increases. Compared with the centrifugation holding time of 900 s, the volume of shrinkage defects at the riser decreases correspondingly after the holding time of 30 s, and the shrinkage effect of the riser is weakened. At the same time, the titanium alloy castings were actually poured, and the test results were consistent with the physical simulation results, which verified the correctness of the physical simulation test results.