[1]李雯,刘宏民,章亚东,等.熊果甙的相转移催化合成法[J].郑州大学学报(工学版),1999,20(02):42-44.[doi:10.3969/j.issn.1671-6833.1999.02.014]
　LI Wen,LIU Hongmin,Zhang Yadong,et al.Phase transfer catalytic synthesis of arbutin[J].Journal of Zhengzhou University (Engineering Science),1999,20(02):42-44.[doi:10.3969/j.issn.1671-6833.1999.02.014]

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熊果甙的相转移催化合成法()

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《郑州大学学报(工学版)》[ISSN:1671-6833/CN:41-1339/T]

卷:

20卷

期数:

1999年02期

页码:

42-44

栏目:

出版日期:

1999-01-01

文章信息/Info

Title:

Phase transfer catalytic synthesis of arbutin

作者:

李雯; 刘宏民; 章亚东; 等.

郑州工业大学化工学院,河南,郑州,450002, 郑州大学化学化工学院,河南,郑州450052, 河南省城建高等专科学校,河南,平顶山,467001

Author(s):

LI Wen; LIU Hongmin; Zhang Yadong; etc

关键词:

熊果甙;  糖甙化反应;  相转移催化法;  合成

Keywords:

Arbutin;  glycoside reactions;  phase transfer catalysis;  Synthesis

DOI:

10.3969/j.issn.1671-6833.1999.02.014

文献标志码:

A

摘要:

对熊果甙的化学合成方法进行了研究.采用相转移催化法,用溴化四丁基铵作催化剂,常压下进行糖甙化反应,所得五乙酰熊果甙经脱保护基后以44%的总收率(以葡萄糖计)得到熊果甙,产物结构经元素分析、红外光谱、核磁共振谱所证实.该方法为常压反应,且原料易得,操作简单,对设备要求不高,具有一定的工业生产价值.

Abstract:

The chemical synthesis method of arbutin has been studied. By phase transfer catalysis, tetrabutylammonium bromide was used as a catalyst and glycoside reaction was carried out under atmospheric pressure, and the pentasylarbutin was obtained by deprotective group with a total yield of 44% (in terms of glucose), and the product structure was confirmed by elemental analysis, infrared spectroscopy and nuclear magnetic resonance spectroscopy. This method is atmospheric pressure reaction, and the raw materials are easy to obtain, the operation is simple, the equipment requirements are not high, and it has certain industrial production value.

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