[1]陈岚,于迦南,王永堂,等.生物医用镁合金的高可靠性设计思路及研究进展[J].郑州大学学报(工学版),2027,48(XX):1-10.[doi:10.13705/j.issn.1671-6833.2026.02.012]
　CHEN Lan,YU Jianan,WANG Yongtang,et al.Research Progress and High-Reliability Design Ideas of Biomedical Magnesium Alloys[J].Journal of Zhengzhou University (Engineering Science),2027,48(XX):1-10.[doi:10.13705/j.issn.1671-6833.2026.02.012]
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生物医用镁合金的高可靠性设计思路及研究进展()
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《郑州大学学报(工学版)》[ISSN:1671-6833/CN:41-1339/T]

卷:
48
期数:
2027年XX
页码:
1-10
栏目:
出版日期:
2027-12-10

文章信息/Info

Title:
Research Progress and High-Reliability Design Ideas of Biomedical Magnesium Alloys
作者:
陈岚 1 , 于迦南 1 , 王永堂 2 , 关绍康1
1. 郑州大学 材料科学与工程学院,河南 郑州 450001;2. 河南省郑州市中心医院,河南 郑州 450007
Author(s):
CHEN Lan 1 , YU Jianan 1 , WANG Yongtang 2 , GUAN Shaokang1
1. School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China; 2. Zhengzhou Central Hospital of Henan Province, Zhengzhou 450007, China
关键词:
生物医用镁合金;  高可靠性设计;  合金化;  组织调控;  腐蚀
Keywords:
biomedical magnesium alloys;  highly reliable design;  alloying;  tissue regulation;  corrosion
分类号:
TG174. 4R318. 08
DOI:
10.13705/j.issn.1671-6833.2026.02.012
文献标志码:
A
摘要:
镁及其合金因优异的生物相容性和力学匹配性，在血管支架、胆道支架、骨组织工程支架、骨钉、骨板、多孔牙科植入物等医用植入体方面表现出巨大的应用潜力，在生物医用材料领域备受瞩目。然而，面对人体复杂多变的生理环境，镁合金耐腐蚀性差，镁合金器械易于降解，导致其性能过早衰退，可靠性不足。因此，在镁合金的设计中，不仅需要考虑不同的体内环境，还需要考虑器件在长期服役过程中的性能变化及可靠性。综述了镁合金的高可靠性设计策略，包括合金成分设计、工艺控制、表面改性、计算机模拟等；总结了目前镁合金在骨科、心血管外科、普外科、口腔科等领域的应用及相关材料的设计工作；提出了生物医用镁合金未来的发展将聚焦于可控降解、材料功能化和智能化设计等方面，为镁合金的临床应用提供参考与借鉴。
Abstract:
Magnesium and its alloys have shown great application potential in medical implants such as vascular stents, biliary stents, bone tissue engineering stents, bone nails, bone plates, and porous dental implants due to their excellent biocompatibility and mechanical matching properties, and have attracted much attention in the field of biomedical materials. However, in the face of the complex and ever-changing physiological environment of the human body, magnesium alloys have poor corrosion resistance and magnesium alloy devices are prone to degradation, leading to premature performance decline and insufficient reliability. Therefore, in the design of magnesium alloys, it is necessary not only to take into account different internal environments but also to consider the performance changes and reliability of the devices during long-term service. This paper reviews the high-reliability design strategies of magnesium alloys, including alloy composition design, process control, surface modification, computer simulation, etc. The current applications of magnesium alloys in orthopedics, cardiovascular surgery, general surgery, stomatology and other fields, as well as the design work of related materials, are summarized. It is proposed that the future development of biomedical magnesium alloys will focus on controllable degradation, material functionalization and intelligent design, etc., providing reference and inspiration for the clinical use of magnesium alloys.

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备注/Memo

备注/Memo:
收稿日期:2025-11-17;修订日期:2026 -02-02
基金项目:国家自然科学基金 资助项目 (52101292) ; 河南省科技研发计划联合基金项目 ( 242301420026) ; 中国博士后科学基金资助项目 (2021M702930)
作者简介:陈岚(1992— ) ,女,河南郑州人,郑州大学副教授,博士,主要从事金属生物材料与免疫研究,E-mail:chenlan@zzu.edu.cn。
更新日期/Last Update: 2026-03-31