[1]单丽红,乔星,李央,等.去氢表雄酮的生物转化、衍生物合成及细胞毒活性研究[J].郑州大学学报(工学版),2013,34(01):62.[doi:10.3969/j.issn.1671-6833.2013.01.015]
　SHAN Li-hongQIAO Xing,Ll Yang,ZHANG Lu-jia,et al.Biotransformation of Dihydroepiandrosterone and the Synthesis andCytotoxic Activities of the16-Benzylidene Derivatives[J].Journal of Zhengzhou University (Engineering Science),2013,34(01):62.[doi:10.3969/j.issn.1671-6833.2013.01.015]
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去氢表雄酮的生物转化、衍生物合成及细胞毒活性研究()
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《郑州大学学报(工学版)》[ISSN:1671-6833/CN:41-1339/T]

卷:
34
期数:
2013年01期
页码:
62
栏目:
出版日期:
2013-01-16

文章信息/Info

Title:
Biotransformation of Dihydroepiandrosterone and the Synthesis andCytotoxic Activities of the16-Benzylidene Derivatives
作者:
单丽红; 乔星; 李央; 等.
郑州大学药学院,河南郑州450001;郑州大学新药研发中心,河南郑州450001, 郑州大学药学院,河南郑州450001;郑州大学新药研发中心,河南郑州450001, 郑州大学药学院,河南郑州450001;郑州大学新药研发中心,河南郑州450001, 郑州大学药学院,河南郑州450001;郑州大学新药研发中心,河南郑州450001, 郑州大学药学院,河南郑州450001;郑州大学新药研发中心,河南郑州450001, 郑州大学药学院,河南郑州450001;郑州大学新药研发中心,河南郑州450001
Author(s):
SHAN Li-hong1; 2QIAO Xing1; 2; Ll Yang1; 2; ZHANG Lu-jia1; 2; JIA0 Kai1; 2; LIU Hong-min1; 2
1.School of Pharmaceutical Science, Zhengzhou University , Zhengzhou 450001, China;2. New Drug Research and Develop-ment Center，Zhengzhou University，Zhengzhou 450001 ，China
关键词:
去氢表雄酮;  卷枝毛霉;  7-羟基化;  16-苯亚甲基衍生物;  细胞毒活性
Keywords:
dihydroepiandrosterone; Mucor cireinelloides ;  7-hydroxylation; 16-benzylidene derivatives; cyto-toxic activity
分类号:
R914.5
DOI:
10.3969/j.issn.1671-6833.2013.01.015
文献标志码:
A
摘要:
去氢表雄酮是一种重要的生物活性物质,也是甾体药物的重要中间体.研究了卷枝毛霉对去氢表雄酮的生物转化,从其发酵液中分离得到两种产物,7α-和7β-羟基去氢表雄酮.并利用Claison-Schimidt缩合反应制备了7α-羟基去氢表雄酮的16-苯亚甲基衍生物,活性测试表明,在16位引入带有不同取代基的苯亚甲基结构可增强此类化合物的细胞毒活性.
Abstract:
Dihydroepiandrosterone (DHEA ) is one important bioactivity compound and one important interme-diate of steroid drugs. It is for the first time to report the biotransformation of DHEA by Mucor circinelloidesand two products was obtained. Furthermore,the 16-benzylidene derivatives were synthesized by Claison -Schimidt reaction. The cytotoxic evaluation showed that these derivatives had better activity than the parentcompound.
更新日期/Last Update: 1900-01-01